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The effect of prostaglandin F-2 infusion on uterine motility in surgically aborted goats

In goats the corpus luteum (CL) is essential for the maintenance of pregnancy (Meites, Webster, Young, Thorp & Hatch, 1951). Cooke, Knifton & Ward (1975) showed that removal of the CL caused a sudden decline in uterine venous plasma concentrations of progesterone and abortion occurred after a consistent interval of 30 h; there was an abrupt increase in the concentration of uterine venous plasma prostaglandin (PG) F about 24 h after removal of the CL, before or coincident with cervical softening and dilatation. The present experiments were designed to examine, on this simplified 'model', any effects of intra-arterial infusions of PGF-2 on uterine motility, cervical dilatation and the interval to abortion.