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Indomethacin and gonadotrophin release from rat pituitaries in vitro

Sundberg, Fawcett, Illner & McCann (1975) have shown that high concentrations of indomethacin (1 and 2·7 mM) can increase the release of LH and FSH from rat pituitary tissue in vitro. Such concentrations, however, have other actions in addition to the inhibition of prostaglandin (PG) synthetase for which the drug is commonly used experimentally (Flower, 1974). The effects of lower concentrations of indomethacin have therefore been tested.