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Effects of 1-p-chlorobenzyl-1H-indazol-3-carboxylic acid (AF 1312/TS) on the fertility of rats

The indazolcarboxylic acids are compounds which have been shown to have antispermatogenic activity (Corsi, Palazzo, Germani, Scorza Barcellona & Silvestrini, 1976). The prototype of the series, 1-p-chlorobenzyl-1H-indazol-3-carboxylic acid or AF 1312/TS, produces changes in the rat seminiferous epithelium within 24 h of a single oral dose. It affects the spermatids, spermatocytes and Sertoli cells without producing any lesions of the spermatogonia or interstitial tissue (De Martino et al., 1975; Silvestrini et al., 1975). Prolonged treatment, up to 6 months in the rat, has shown that the substance has no toxic effects or any adverse effects on the accessory sex organs of adult animals (Burberi, Catanese, Cioli, Scorza Barcellona & Silvestrini, 1975).