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Effects of an inhibin-like factor present in bovine and porcine follicular fluid on gonadotrophin levels in ovariectomized rats

De Jong & Sharpe (1976) recently observed that bovine follicular fluid from which steroids had been removed reduced peripheral levels of FSH but not of LH when injected into newly castrated male rats. The effect was ascribed to a factor resembling testicular inhibin. In the present report, observations were extended to the effects of this inhibin-like factor on FSH and LH levels in female rats. Attention has also been paid to the question of whether the factor is present in species other than the cow and whether the factor is present in antral follicles of all sizes.