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Lack of an inhibitory influence of oocytes upon luteinization of porcine granulosa cells in culture

Nalbandov (1972) suggested that the ovum produces a "luteostatic" substance which prevents luteinization of granulosa cells. This suggestion was derived from three lines of observation: (1) surgical ovectomy in vivo induced luteinization and increased the output of progesterone into the ovarian venous blood of rabbits (El-Fouly, Cook, Nekola & Nalbandov, 1970) and pigs (Nalbandov, 1972); (2) rat granulosa cell monolayers cultured with only a few oocytes luteinized, whereas those cultured in the presence of many ova retained their granulosa cell morphology (Nekola & Nalbandov, 1971); and (3) oocytic degeneration on the 3rd day of culture of rat follicles coincided with morphological luteinization of the mural granulosa (Stoklosowa & Nalbandov, 1972).