This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by MARCUS, G. J. Articles by SHELESNYAK, M. C. Search for Related Content PubMed PubMed Citation Articles by MARCUS, G. J. Articles by SHELESNYAK, M. C.

STUDIES ON THE MECHANISM OF DECIDUALIZATION

Summary.: A single intraperitoneal injection of pyrathiazine induces extensive decidualization of the progravid uterus of the rat. This action was considered to be mediated by the release of histamine. The present study was undertaken to show that pyrathiazine, an antihistaminic drug, causes histamine release.

Injection of pyrathiazine in rats produced a characteristic histaminerelease syndrome, and caused a twofold increase in the urinary excretion of histamine. Pretreatment with pyrathiazine protected rats from the lethal effects of challenge doses of histamine-liberator Compound 48/80 but not of histamine.

These actions of pyrathiazine demonstrate that it releases histamine in the rat, and that its effectiveness as a decidual inducer is consistent with the postulated role of histamine in decidual induction.

This article has been cited by other articles:

				X Zhao, W Ma, S. Das, S. Dey, and B. Paria Blastocyst H(2) receptor is the target for uterine histamine in implantation in the mouse Development, January 6, 2000; 127(12): 2643 - 2651. [Abstract] [PDF]

				B. C. Paria, N. Das, S. K. Das, X. Zhao, K. N. Dileepan, and S. K. Dey Histidine Decarboxylase Gene in the Mouse Uterus Is Regulated by Progesterone and Correlates with Uterine Differentiation for Blastocyst Implantation Endocrinology, September 1, 1998; 139(9): 3958 - 3966. [Abstract] [Full Text] [PDF]