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Effect of IUDS on uterine cyclic AMP in rabbits

The mechanism(s) whereby an intrauterine device (IUD) prevents implantation are poorly understood (Eckstein, 1970). Sim (1974) showed that the presence of an IUD in the rat uterus was associated with an increase in cyclic AMP content and adenyl cyclase activity. Cyclic AMP has been implicated in a variety of uterine biosynthetic processes (Hechter, Yoshinaga, Halkerston & Birchall, 1967) and in the control of spontaneous uterine contractions (Johansson & Anderson, 1975). The present study was designed to determine the effect of a plastic and copper-bearing IUD on levels of cyclic AMP in the uteri of oestrous rabbits.