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The secretion of prostaglandin F from the autotransplanted uterus of the ewe

Prostaglandin (PG) F-2 is involved in a number of reproductive functions, including luteolysis (Goding, 1974) and menstruation (Pickles, Hall, Best & Smith, 1965). Luteolysis in sheep is controlled by a local feedback loop operating between the uterus and the corpus luteum, and menstruation in primates is also directly controlled by the ovarian steroid hormones. A fuller knowledge of how these hormones influence the endometrium to produce and release PGF-2 should lead to a better understanding of both luteolysis and menstruation.

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