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Production of prostaglandin F by rabbit granulosa cells and thecal tissue

Prostaglandin production within the Graafian follicle may be of importance in relation to steroidogenesis and ovulation (see Lindner et al., 1974). In culture, human and rabbit follicles synthesize prostaglandin (PG) F, and this capacity can be stimulated by exogenous gonadotrophins (Plunkett, Moon, Zamecnik & Armstrong, 1975; Moon, Zamecnik & Armstrong, 1974). However, the cell type responsible for this prostaglandin production has not been established. Previous studies showed that granulosa cells from preovulatory follicles of the rabbit secreted PGF when cultured as a monolayer for 10 days (Challis, Erickson & Ryan, 1974), but the activity of thecal tissue was not examined. In the present study we have compared the capacity of granulosa and thecal cells to produce PGF in tissue culture, and have observed the effects on this capacity of exogenous gonadotrophin, arachidonic acid and oestradiol.