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Determination of a sensitive period for the induction of the maternal pregnancy reaction in the ferret

Traumatization of an isolated segment of the ferret uterus on Day 12 of gestation (the day of implantation) results in the development of a maternal pregnancy reaction at the site of the trauma. This reaction consists of the formation and subsequent necrosis of symplasmal nests of endometrial epithelial cells and hypertrophy of the maternal capillary endothelium, and the cytology is identical to that of the endometrial reaction in the placental region of the uterus during normal pregnancy (Beck, 1974). The development of a maternal pregnancy reaction at times during gestation other than Day 12 has not been investigated and the present study was therefore undertaken to see whether a sensitive period existed.