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NATURE OF THE STIMULUS OF THE COPULATION-INDUCED RISE IN LACTIC DEHYDROGENASE ACTIVITY IN THE RABBIT OVIDUCT

Department of Biochemistry, All-India Institute of Medical Sciences, New Delhi-110 016, India

(Received 26th February 1975)

It has been reported that there is an increase in the activity of acid phosphatase, alkaline phosphatase and lactic dehydrogenase in different regions of the rabbit oviduct within 14 hr after mating (Varma & Talwar, 1973; Varma et al., 1974). Concomitant with the increase in the total activity of the lactic dehydrogenase (LDH; L(+)-lactate: NAD⁺ oxidoreductase, EC 1.1.1.27 [EC] ), there is a shift in the isoenzymic pattern of the enzyme, and the M-form of the enzyme (which favours the formation oflactate) increases markedly in the organ (Varma et al., 1974). The stimulus for these changes is not yet known, but is presumably hormonal or neural. The present investigations were undertaken to examine the factor(s) responsible for these metabolic changes.

Sexually mature female rabbits, bred in the Institute colony and weighing 2–2·5 kg, were used.