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THE DEVELOPMENT OF THE MOUSE OVARY AND ITS RESPONSE TO EXOGENOUS GONADOTROPHINS

Summary.: Immature mice aged 14 to 49 days were treated with a single injection of 4 i.u. HCG, or 3 i.u. PMSG followed 48 hr later by 2 i.u. HCG. After treatment with HCG alone the number of oocytes which were ovulated rose gradually from Day 21 to Day 28 and then remained constant, while the combined PMSG+ HCG treatment induced a peak response between Days 24 and 28. The percentage of animals responding also varied with age and treatment. After the combined PMSG+ HCG treatment, 90% of the animals ovulated on Day 21, while a similar proportion was not achieved in response to HCG alone until Day 32. The variation in response with age and treatment was related to follicular development within the ovary.

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