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THE EFFECT OF SERIAL UTERINE BIOPSIES AND HYSTERECTOMY ON PERIPHERAL BLOOD LEVELS OF TOTAL UNCONJUGATED OESTROGEN AND PROGESTERONE IN THE BITCH

Department of Surgery and Obstetrics, Royal Veterinary College Field Station, Hawkshead Lane, North Mimms, Nr Hatfield, Hertfordshire

(Received 11th March 1975)

The role of ovarian steroids in the aetiology of cystic endometrial hyperplasia in the bitch has been under discussion for some time. Earlier workers thought that this condition was due to abnormal oestrogen production (Hetzel, 1935; Bloom, 1954; Schulze, 1955). Teunissen (1952) and Dow (1959), however, produced evidence suggesting that prolonged high levels of progesterone were the cause of cystic endometrial hyperplasia in the bitch. The present work reports the changes in total unconjugated oestrogen and progesterone concentrations in the peripheral blood of bitches subjected to serial biopsies, which result in the development of uterine lesions without hormone treatment (Hadley, 1975a), and the effect of hysterectomy on the levels of these steroids.

One multiparous beagle, Bitch A, and two nulliparous mongrels, Bitches F and J, were used in this