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EFFECT OF PROSTAGLANDIN F₂ ON SERUM PROLACTIN AND LH CONCENTRATIONS IN MALE AND FEMALE RATS

Instituto de Investigacion Médica, Mercedes y Martin Ferreyra, Casilla de Correo 389, Córdoba, Argentina

(Received 10th March 1975)

Prostaglandin F₂ (PGF₂) has been shown to induce prolactin release in pregnant rats (Deis, 1971; Vermouth & Deis, 1972). Treatment with PGF₂ may induce lactogenesis in women after early termination of pregnancy (Smith et al., 1972), accompanied by a significant increase in serum prolactin level (Yue et al., 1974). Harms et al. (1973) injected PGE₁ into the third ventricle in castrated female rats and found increased plasma prolactin levels, although PGE₂, PGF₁ and PGF₂ had no effect. Intraventricular or intravenous injection of PGE₂ induced a significant rise of plasma LH. According to Batta et al. (1974), intracarotid injection of PGF₂ resulted in a greater release of FSH than LH in ovariectomized rats treated with oestrogen, but had no effect on male rats. In