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PREGNANT MARE SERUM GONADOTROPHIN: RATE OF CLEARANCE FROM THE CIRCULATION OF SHEEP

Summary.: The process involved in the disappearance of PMSG from the blood of sheep, following a single intravenous injection, has been separated into two exponential components. Values (mean±S.E.) calculated from experiments on five animals were: metabolic clearance rate (37·8±1·6 ml hr^–1); rate constant of disposal (0·0315±0·0016 hr^–1); half-time of disposal (21·2±1·1 hr). The stage of the oestrous cycle, ovariectomy and the dose of PMSG used had no apparent effect on these values.

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