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STUDIES ON THE MECHANISM OF THE HYAMINE-INDUCED ACROSOME REACTION IN EJACULATED BOVINE SPERMATOZOA

Agricultural Research Council Institute of Animal Physiology, Babraham, Cambridge CB2 4AT

A basic requirement for membrane fusion is that the two membranes must be brought sufficiently close together to allow fusion. This is complicated by the fact that most intracellular membranes have the same overall negative charge, at least when isolated. It has been pointed out that on theoretical grounds there is less of an energy barrier to fusion if at least one of the membranes is distorted to form a narrow protrusion (Poste & Allison, 1973). Most fusion reactions occur rapidly and their exact site is difficult to predict. In this respect the acrosome reaction of spermatozoa has the advantage that there is a large area of membranes between which fusion occurs. This electron microscope study of that fusion process is part of a wider investigation (Wooding & O'Donnell, 1971; Wooding, 1973) to see whether the complex sequence of

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