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VARIATIONS IN THE SERUM CONCENTRATION OF A HUMAN PREGNANCY-ASSOCIATED -MACROGLOBULIN DURING PREGNANCY AND AFTER DELIVERY

Department of Biochemistry, University of Strathclyde, 204 George Street, Glasgow G1 1XW

(Received 30th December 1974)

Human pregnancy is associated with the appearance in the blood of additional proteins not commonly identifiable in the plasma of non-pregnant subjects (MacLaren, Thornes, Roby & Reid, 1959; Bohn, 1971; Lin, Halbert, Kiefer, Spellacy & Gall, 1974). One of these is readily detectable by electrophoretic and immunochemical methods (Smithies, 1955; Afonso & de Alvarez, 1964; Studd, Blainey & Bailey, 1970), and has been isolated, characterized and found to be a high molecular weight -globulin containing approximately 10% carbohydrate (Stimson & Eubank-Scott, 1972). This pregnancy-associated -macroglobulin (PAM) is not unique to pregnancy and its concentration has been determined in the serum of subjects with a variety of conditions (Stimson, 1973a, 1974). Treatment of both males and females with oestrogens results in elevations in the PAM serum level (Horne & co-authors, 1973; Berne, 1973; Stimson, 1974),

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