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CHROMOSOMAL ANALYSIS OF RABBITS DERIVED FROM EGGS FERTILIZED IN VITRO

Department of Infant Development, Clinical Research Centre, Harrow, Middlesex HA1 3UJ, and Department of Obstetrics and Gynaecology, University College Hospital, London

(Received 4th October 1974)

There has been considerable interest in recent months in the possibility of using fertilization in vitro and embryo transfer techniques to alleviate certain forms of human infertility.

These techniques have been used successfully in the rabbit (Chang, 1959; Fraser & Dandekar, 1973), mouse (Whittingham, 1968; Hoppe & Pitts, 1973) and rat (Toyoda & Chang, 1974). In general, relatively few embryos have been transferred and little reference to the offspring has been made other than to note phenotypic normality. Fertilization in vitro has also been described for human eggs (Edwards, Steptoe & Purdy, 1970) and more than twelve such eggs have subsequently been transplanted (Robertson, 1974), although no pregnancies have yet been reported (de Kretzer & co-authors, 1973). The reasons for failure are unknown, but the