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SHIFTS IN ATP SYNTHESIS DURING PREIMPLANTATION STAGES OF MOUSE EMBRYOS

Summary.: The actual and potential activities of the cytochrome system were studied in cleavage-stage mouse embryos. Activities were determined by assaying embryos for total ATP and the rates of [³²P]ATP synthesis both before and after their incubation in medium supplemented either with an energy coupling site inhibitor (antimycin, amytal or cyanide) or with the FADH-linked substrate, succinate. The data indicate that there are three major shifts in the mode of ATP production during preimplantation stages: the first, between the two-cell and late four-cell stages; the second, between the eight-cell and late morula stages; and the third, between the late morula and late blastocyst stages. These data are discussed in relation to studies on the energy metabolism of cleavage and blastocyst stage mouse embryos.

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