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THE EFFECT OF DRUGS ON IMPLANTATION IN RATS WITH AN INTRAUTERINE DEVICE IN ONE HORN OF THE UTERUS

Chulalongkorn Hospital Medical School, Bangkok, Thailand

(Received 15th July 1974)

The mechanism of the antifertility effect of the IUD has not been clearly elucidated. Recent experimental results suggest that prostaglandins released by such a device could inhibit implantation (Chaudhuri, 1971; Saksena, Lau & & Castracane, 1974), either by expelling the blastocyst through uterine contractions or by exerting a luteolytic effect.

This hypothesis has been tested by administering acetyl salicylic acid and indomethacin, at dose levels known to prevent formation of prostaglandins, to rats with an IUD in one horn of the uterus. Similar experiments were carried out on rats treated with progesterone, LH or LH + prolactin which are known to counteract the luteolytic effect of prostaglandins (Fuchs & Mok, 1973).

A silk thread suture was inserted into the lumen of one horn of the uterus as described by Tarak & Chaudhury (1965) and the rats (150 to 200 g) were

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