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THE EFFECT OF MESTRANOL AND LYNOESTRENOL ON UTERINE HISTAMINE IN THE RAT

Department of Pharmacology, Faculty of Pharmacy, University of Alexandria,Alexandria, Egypt Arab Republic

(Received 1st July 1974)

Shelesnyak (1959) first suggested that histamine might be the inducing factor for decidualization and that it might be involved in the process of implantation in the rat (Shelesnyak & Kraicer, 1964). Treatment with oestrogen results in histamine depletion from the rat uterus (Szego, 1966; McKercher, Van Orden, Bhatnagar & Burke, 1973), and it was suggested that histamine might be involved in the hyperaemia and oedema stimulated by oestrogen (Szego, 1966). Recently, it has been reported that treatment with the contraceptive steroids, mestranol and lynoestrenol, alone or in combination, resulted in a decrease in histamine content per ovary in the rat (Abdel-Aziz, Ghazal & Daabees, 1974). The present work was undertaken to study the effect of mestranol and lynoestrenol on the histamine content of the rat uterus.

Fifty-six virgin female albino rats with a