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STUDIES ON THE DEVELOPMENT OF THE IMPLANTATION REACTION IN THE MOUSE UTERUS: INFLUENCE OF ACTINOMYCIN D

Summary.: The influence of actinomycin D on the implantation of blastocysts has been studied in mice. The early stages of implantation, the Pontamine sky blue reaction and stromal oedema take place normally and the blastocyst is stimulated to develop. Decidualization, however, is delayed and the degeneration of the uterine epithelium around the blastocyst is inhibited, suggesting that the latter is dependent on DNA-directed messenger RNA synthesis whereas the initial implantation changes and activation of the blastocyst are not.

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