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EFFECTS OF ASPIRIN ON PROSTAGLANDIN AND FRUCTOSE LEVELS IN HUMAN SEMEN

Summary.: The object of this investigation was to determine how completely prostaglandin synthesis can be inhibited by high doses of aspirin (3·6 and 7·2 g/day) in man.

Concentrations in human semen of fructose and of prostaglandins E and 19-hydroxy A and B were measured daily before, during and after 3-day courses of aspirin administration to two subjects, using absorptiometric methods. Recoveries of prostaglandin E were estimated with a radioactive tracer; prostaglandin F was measured by biological assay.

At the higher aspirin dose, prostaglandin E levels were reduced by 80%; this reduction was accompanied by signs of aspirin toxicity. Fructose levels were unaffected.

It is concluded that highly toxic doses of aspirin would be required to block prostaglandin synthesis completely.