This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by MUNSHI, S. R. Articles by NILSSON, O. Search for Related Content PubMed PubMed Citation Articles by MUNSHI, S. R. Articles by NILSSON, O.

MORPHOLOGICAL EFFECT OF ANTISERUM TO LUTEINIZING HORMONE ON EARLY PREGNANCY IN MICE

Rabbit antiserum to ovine LH is capable of neutralizing the endogenous activity of mouse LH (Munshi & Rao, 1967). Administration to mated female mice on any one day from Days 2 to 7 after mating results in the inhibition of pregnancy. Since this inhibition can be overcome only by the continuous administration of progesterone, it has been suggested that the antiserum blocks pregnancy by inhibiting progesterone synthesis by the corpus luteum (Munshi, Purandare & Rao, 1972). These studies, however, do not indicate at what stage pregnancy is affected.

Since the various stages of pregnancy differ morphologically, microscopy has been used to examine the early stages of pregnancy in mice injected with antiserum to LH in order to find out when pregnancy is affected.

Random-bred albino mice of the NMRI strain were used. Females were placed with males overnight and examined for the presence of a vaginal plug the next morning.