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EXCESS DIETARY METHIONINE AND PREGNANCY IN THE RAT

Pregnancy maintenance in the rat is seriously impaired by diets containing less than 6% protein (Nelson & Evans, 1953). Reproductive failure can also occur when a single amino acid is deleted from an otherwise complete diet (Niiyama, Kishi & Inoue, 1970). While considerable attention has been given to pregnancy and undernutrition, relatively little research has involved the excess of single amino acids (Harper, Benevenga & Wohlheuter, 1970). Kerr & Waisman (1967) fed as much as 7% phenylalanine in a normal diet to pregnant rats without affecting pregnancy. Intraperitoneal injections of leucine into pregnant rats on Days 6 to 9 caused fetal resorptions (Persaud, 1969). When fed, however, leucine at a 10% level in a 27% casein diet did not modify the pregnancy but the number of surviving litters was reduced when the leucine supplement was added to a 9% casein diet (Cohlan & Stone, 1961). Methionine, which stimulates the growth

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