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CHEMICAL SYMPATHECTOMY OF THE RABBIT OVIDUCT USING 6-HYDROXYDOPAMINE

Summary.: Chemical sympathectomy followed transluminal perfusion of the rabbit oviduct with 6-hydroxydopamine (6-OHDA). Histofluorescence studies 1 week after perfusion revealed an absence of formaldehyde-norepinephrine(NE)-induced fluorescence in treated oviducts while contralateral control oviducts which were not perfused exhibited normal fluorescence. Endogenous NE concentrations of treated and control oviducts and their associated uterine horns were measured biochemically 1 week after perfusion. A dose-dependent decrease in NE was demonstrated in 6-OHDA-perfused oviducts. By contrast, contralateral control oviducts and both uterine horns exhibited no significant decrease in endogenous NE until doses of 6-OHDA in excess of those required for functional denervation were perfused through treated oviducts.