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INTERACTION OF HUMAN SPERM ACROSOMAL PROTEINASE WITH HUMAN SEMINAL PLASMA PROTEINASE INHIBITORS

Summary.: Human sperm acrosomal proteinase is immediately inhibited by the Fraction I (mol. wt. 12,700) and Fraction II (mol. wt. 5,400) proteinase inhibitors of human seminal plasma. The Fraction II inhibitor inhibits acrosomal proteinase much more effectively than the Fraction I inhibitor, having an association constant of 5·0 x 10⁸ M^–1 and a dissociation constant of 2 ·0 x 10 ^{– 9} M. The results provide further evidence for the possible rôle of the Fraction II inhibitor in the reproductive process.