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COMPENSATORY OVARIAN HYPERTROPHY CAN BE OBTAINED IN NEONATAL RATS

Several recent studies have disagreed as to whether compensatory ovarian hypertrophy (COH) occurs in rats younger than 20 days of age. In female rats hemiovariectomized at 10 days of age by Ojeda & Ramírez (1972), there was no significant increase in the weight of the remaining left ovary at 12, 15 and 20 days of age when compared to that in animals subjected to sham operation. Baker & Kragt (1969) reported that excising the right ovary at birth did not cause the remaining ovary to be significantly heavier than the left ovary in control rats at 10, 15 and 20 days of age. By contrast, Gerall & Dunlap (1971) and Dunlap, Preis & Gerall (1972) have reported significant COH in the right ovary within 10 days in rats hemispayed at birth. Negative results have been interpreted