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It has been demonstrated that thyroxine is essential for normal fertility in rats and rabbits (Chu, 1944-46; Krohn & White, 1950); a study by Parrott, Johnston & Durbin (1960) included parathyroid hormone (PTH) as well as thyroxine (L-T4). The present preliminary study was undertaken to investigate whether thyrocalcitonin (TCT) and PTH have any influence on implantation and early gestation in rats.
Thirty, 2-month-old, female Charles River rats (Charles River Breeding Laboratory, Waltham, Mass.) with an average body weight of 208 g were randomly allocated to six equal groups. They were housed in an air-conditioned room, exposed to 14 hr of light and had free access to Purina lab pellets and tap water. On the 1st day of pregnancy (the day when spermatozoa were detected in vaginal smears after the females were placed overnight with males
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