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EFFECT OF HEMIOVARIECTOMY ON SERUM FSH AND LH LEVELS DURING THE OESTROUS CYCLE IN THE RAT

A possible explanation for the compensatory increase in weight and function of the remaining ovary in the rat following hemiovariectomy is that gonadotrophin secretion increases due to reduced gonadal steroid levels. The observation that increased amounts of exogenous gonadotrophins are required in hypophysectomized rats to increase the ovarian weight and numbers of ovulations in hemiovariectomized rats to the levels in intact rats (Greenwald, 1968) supports this theory. Efforts to detect changes in circulating gonadotrophin levels following hemiovariectomy in the rat have been only partially successful. Edgren, Parlow, Peterson & Jones (1965) were unable to detect changes in either FSH or LH following removal of one ovary. Benson, Sorrentino & Evans (1969), however, reported that plasma FSH was elevated 4 days after hemiovariectomy.

Since hemiovariectomy on the day of oestrus leads