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EFFECT OF CYPROTERONE ACETATE ON SPERM CONCENTRATION, SEMINAL FLUID VOLUME, TESTICULAR CYTOLOGY AND LEVELS OF PLASMA AND URINARY ICSH, FSH AND TESTOSTERONE IN NORMAL MEN

Summary.: Cyproterone acetate (CA) was administered in a dose of 200 mg/day to six normal men for a period of 16 to 20 weeks. A striking reduction in sperm count, libido and potency was observed, while moderate decreases were detected in testicular germ cell numbers, and testosterone levels in both plasma and urine. No significant change was seen in levels of plasma or urinary ICSH, FSH or in Leydig cell morphology or number. It is concluded that CA is acting directly or indirectly upon the seminiferous tubules to produce a decrease in spermatogenesis which, at least partially, explains the dramatic drop in ejaculate sperm concentration. The observed drop in plasma and urinary testosterone levels was not accompanied by a concomitant drop in plasma or urinary ICSH or Leydig cell number. This could result from an inhibition in testosterone secretion by the action of CA.

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				R. A. Anderson and D. T. Baird Male Contraception Endocr. Rev., December 1, 2002; 23(6): 735 - 762. [Abstract] [Full Text] [PDF]