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A COMPARISON OF SCREENING TESTS FOR ANTI-SPERM ACTIVITY IN THE SERUM OF INFERTILE WOMEN

Summary.: Evidence of humoral anti-sperm activity was sought in the female partners of 196 couples with unexplained and organic infertility, and in a control group of fifty pregnant women. Two tests were used, sperm micro-agglutination and sperm immobilization. The micro-agglutination test demonstrated little difference in incidence of positive reactions in patients with unexplained and organic infertility and yielded an 18% incidence in the pregnant control patients.

The results of the sperm immobilization test showed a clear disparity in patients with unexplained infertility compared with those in the organic infertility and pregnancy groups. A comparison of these results with those obtained by other workers, using the same and other methods, suggests that the sperm immobilization test provides the most reliable single method for the detection of circulating anti-sperm activity with possible clinical significance.