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EFFECTS OF CYPROTERONE ACETATE ON THE ADENOHYPOPHYSIAL CELLS OF MALE RATS

Summary.: Cyproterone acetate, a synthetic antiandrogenic steroid, caused a marked reduction in the weights of the accessory sex glands when given to male rats. The compound also affected the anterior lobe of the pituitary causing a decrease in the numbers of growth-hormone-producing cells. Cyproterone acetate did not inhibit spermatogenesis and the Leydig cells were normal.

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				J. C. O'Connor, S. R. Frame, and G. S. Ladics Evaluation of a 15-Day Screening Assay Using Intact Male Rats for Identifying Antiandrogens Toxicol. Sci., September 1, 2002; 69(1): 92 - 108. [Abstract] [Full Text] [PDF]