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THE EFFECT OF PARTIAL REMOVAL OF THE CORPORA LUTEA ON THE OVARIAN CYCLE IN THE RAT

Studies on compounds that inhibit luteal progesterone synthesis and/or secretion in the rat (Mason, Tinsley & Cochrane, 1969; Tinsley, Rathmacher & Cochrane, 1970) have led to the development of a cursory screen for such activity which uses the induction of an oestrous or pro-oestrous vaginal smear in the pseudopregnant rat as an end-point. A number of reports (McKeown & Zuckerman, 1937; Rothchild, 1960; Zeilmaker, 1965; Smalstig, Bennett, Shaar & Cochrane, 1971) have indicated that this is probably justified since complete removal of the CL of pseudopregnant rats will cause the appearance of an oestrous, or pro-oestrous, vaginal smear within 2 to 7 days.

The present study was undertaken to equate the degree of luteal suppression necessary for the expression of oestrous or pro-oestrous vaginal smears in pseudopregnant rats with the maximum number of