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SYNTHESIS OF DNA AND MITOSIS IN RABBIT UTERI AFTER OESTROGEN AND PROGESTERONE INJECTIONS, AND DURING EARLY PREGNANCY

In oestrogen-primed mice, progesterone stimulates stromal mitosis and inhibits epithelial mitosis (Finn & Martin, 1967; Martin & Finn, 1968). In rabbits, however, endometrial proliferation is stimulated by progesterone. This report describes DNA synthesis (measured by [³H]thymidine incorporation) and mitosis in the uterine epithelium of ovariectomized rabbits treated with oestrogen and progesterone, and in intact animals during early pregnancy.

Mature New Zealand White rabbits were given 5·0 mg colchicine (1·0 mg/kg body weight) in 1·0 ml water intraperitoneally 6 hr before death. The `mitotic index' refers to the percentage of mitoses accumulated during this 6 hr period. One hour before death, the rabbits were anaesthetized with sodium pentobarbitone and 100µCi [³H]methylthymidine (s.a. 20 Ci/mmol, from