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CHLORCYCLIZINE-INDUCED CHANGES IN THE OVARIES AND THE UTERUS OF RATS

Chlorcyclizine is a substituted piperazine which is a hypocholesterolaemic and antihistaminic agent (Barnhart & Sefranka, 1966) as well as a potent inducer of hepatic microsomal enzymes (Conney, 1967). In pregnant rats, the drug has been reported to lead to abortion and abnormal fetal development (King, Weaver & Narrod, 1965). In two previous studies, we reported that chlorcyclizine (CZ), when fed in the diet at the level of 0·18% to male pubertal rats, is capable of producing severe damage to the testicular germinal epithelium and Leydig cells (Wong & Hruban, 1972). In the male accessory sex glands, two types of changes are observed : those secondary to the androgen deficiency accompanying Leydig cell damage, and those due to a direct cytotoxic effect of CZ (Wong, Hruban & Slessers, 1972). The direct cytotoxic effect