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ANILS AS POSSIBLE ANTIFERTILITY AGENTS

Summary.: A series of five anils and a phenylamine derivative of one of them have been tested for antifertility effect in female albino rats at a daily dose of 20 mg/kg administered orally from Days 1 to 7 of pregnancy. It was found that N-(2-chloro-l-naphthylidene)-3-amino-2:6-lutidene inhibited fertility in nine out of ten animals. The mechanism of action of this compound and the structure/action relationship of the present series of anils is discussed.