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THE ORIGIN, CLASS AND SPECIFICITY OF IMMUNOGLOBULINS IN BOVINE CERVICO-VAGINAL MUCUS: VARIATION WITH PARENTERAL IMMUNIZATION AND LOCAL INFECTION WITH VIBRIO FETUS

Summary.: Cervico-vaginal mucus agglutinins occurred in heifers following either parenteral immunization with Vibrio fetus or transfer of serum from hyperimmunized cattle. Serum IgG was transported into the lumen of the reproductive tract. Thus, while serum agglutinins were of IgG and IgM classes, those in mucus were solely IgG. Agglutinins induced by immunization were predominantly of whole-cell specificity whereas those stimulated by local infection of the reproductive tract with V. fetus were directed toward the O-determinant. The O-agglutinins in vaginal mucus were of the IgA class and their synthesis within the reproductive tract appeared likely.