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IMMUNOLOGY AND PLACENTATION IN VIVIPAROUS INVERTEBRATES

The delayed rejection of allografted tissue in the presence of specific antibodies (Kaliss, 1958, 1962) has been considered as a possible mechanism for the maintenance of the fetal-maternal relationship in mammalian reproduction. Experiments which demonstrate the abrogation of cellular immunity to mouse embryonic cells by serum from pregnant or multiparous female strain animals have been taken to indicate that specific 'blocking' antibodies might prevent the cytotoxic action of maternal lymphocytes on embryonic cells (Hellstrom, Hellstrom & Braun, 1969). In turn, it has been suggested (Hellstrom & Hellstrom, 1970) that this might be the mechanism underlying the paradoxical survival of the mammalian conceptus as an allograft.

The existence of immunological enhancement, as this phenomenon is called, depends on the simultaneous presence in a particular system of