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IMPLANTATION IN LACTATING RATS TREATED WITH INSULIN

The infertility of female mice following starvation or insulin administration was attributed to inhibition of adenohypophysial gonadotrophic function due to hypoglycaemia (McClure, 1967). Cows with low blood glucose were less fertile than cows with a rising blood glucose level at about the time of mating (McClure, 1965).

In earlier work, we found that restricting the food consumption of lactating rats to 50% of that of a group of rats on unrestricted food intake inhibited implantation until the restriction was lifted on the 18th day of pregnancy-lactation, although there was no decrease in blood glucose (Shapira, 1969). Since the process of implantation is gonadotrophin-dependent (Psychoyos, 1967), it seemed of interest to study the effect of insulin-induced hypoglycaemia unaccompanied by food restriction.

Twenty-four rats mated post partum were allocated