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THE EFFECT OF PROSTAGLANDIN E₁ ON RABBIT SPERM TRANSPORT IN VIVO

Summary.: The effect of prostaglandin E₁ (PGE₁) on sperm transport in twenty-one artificially inseminated rabbits was investigated. The female genital tracts were sectioned hr or 2 hr after insemination with equivalent numbers of spermatozoa and examined for sperm transport. The inseminate used in each test animal contained 75 µg PGE₁.

The average number of spermatozoa recovered from the uteri and oviducts of the test groups was greater than that of the control groups. In the group killed hr after insemination, 1·8 times as many spermatozoa were recovered in the test group. Nearly 18 times as many spermatozoa on the average were recovered from the test animals killed 2 hr after insemination. However, this was only significant for the group killed 2 hr after insemination (P = 0·004). Significantly greater numbers of spermatozoa were found in the oviducts of test animals killed 2 hr after insemination than in controls (P = 0·014).

This study shows that a high dose of PGE₁ in seminal plasma aids sperm transport in the rabbit female genital tract.

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