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FEEDBACK REGULATION BY OESTRADIOL OF OVARIAN FUNCTION IN JAPANESE QUAIL

Summary.: Feedback regulation of gonadotrophin release from the adenohypophysis by 17 β-oestradiol was examined in breeding female Japanese quail. Implants of the steroid in the preoptic-supraoptic (nuclear) regions, in ventral regions of the infundibular nuclear complex or in the adenohypophysis resulted in a 'persistent oestrous'-like syndrome. Ovulation was prevented, but the weight and follicular size of the ovary and the weight of the oviduct did not differ from control (cholesterol implants or oestradiol implants outside of the hypothalamus) values. Since implants of cholesterol in identical regions of the hypothalamus had no effect on ovarian function, and since ovulation recurred in 10 or 16 days, depending on the site of implantation, the effects observed are attributed directly to the hormone contained in the implant and not to a physical obstruction in the hypothalamus. It is suggested that oestradiol is involved in the regulation of release of LH from the adenohypophysis.