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ANTIOESTRADIOL SERUM IN IMMATURE HAMSTERS

Antioestradiol serum (anti-E₂) inhibited the uterine weight increases caused by HCG in immature mice and rats (Ferin, Zimmering, Lieberman & Vande Wiele, 1968). When anti-E₂ was injected into rats 2 hr before an injection of [³H]E₂, Ferin et al. (1968) found reductions in uterine, ovarian and pituitary weights when these were compared with the weights of similar organs in rats not injected with anti-E₂. It is believed that anti-E₂ prevents LH release and may not necessarily affect the ovary, as shown when HCG caused ovulation even when anti-E₂ was injected (Ferin, Tempone, Zimmering & Vande Wiele, 1969). In rats which received PMSG and anti-E₂, ovulation was restored by HCG, again giving evidence that anti-E₂ acts by inhibiting lh release (Ferin, Zimmering & Vande Wiele, 1969).

The use of anti-E₂ in hamsters has not been reported. This is an account