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THE EFFECT OF THE OESTROUS CYCLE, PREGNANCY AND REPRODUCTIVE HORMONES ON THE KININASE ACTIVITY OF RAT BLOOD

Summary.: The kininase activity of female rat blood was found not to change during the oestrous cycle. In pregnant rats, the kininase levels were found to decrease significantly with advancing gestation, reaching the lowest level around Day 20 of pregnancy. There was a rise towards normal levels in lactating rats but the normal non-pregnant level had not been attained by Day 14 of the puerperium.

The maternal blood volume was shown to increase with advancing gestation until Day 20, when it levelled out.

Administration of oestrogens to non-pregnant rats caused a decrease in kininase activity whereas progestagens did not have a significant effect.