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BIOLOGICAL ACTIVE LIFE OF PMSG IN MICE WITH SPECIAL REFERENCE TO FOLLICULAR ABILITY TO OVULATE

Summary.: Experiments were designed to determine whether PMSG is essential for the continued maturation of follicles whose initial development is stimulated by the hormone in immature mice. Anti-PMSG serum (APS), prepared in rabbits, was used at various times after pretreatment with PMSG to determine the time required for PMSG to mature follicles. Follicular maturity was tested by the ovulatory response to HCG.

When HCG was given 54 to 60 hr after PMSG, maximum ovulation was obtained. When APS was given 54 hr, followed by HCG 60 hr, after PMSG, the percentage ovulation rate decreased significantly from that of the corresponding control group in which APS and HCG were given simultaneously 54 hr after PMSG. When HCG was given 72 hr after PMSG, ovulation did not occur regularly. When a small amount of supplementary PMSG was given 58 hr after the initial dose, ovulation was induced regularly by HCG 72 hr after pretreatment with PMSG.

From these experiments, it is concluded that a small amount of PMSG remains in the circulating blood up to 54 to 60 hr after the pretreatment with PMSG in immature mice. Blood levels of PMSG decrease below the threshold for the maintenance of follicles 72 hr after pretreatment.

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