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DNA CONTENT AND MORPHOLOGICAL PROPERTIES OF PRESUMABLY ANEUPLOID SPERMATOZOA OF TOBACCO MOUSE HYBRIDS

Summary.: A sharp reduction in fertility of the F₁ hybrids between the tobacco mouse (M. poschiavinus) and the laboratory mouse can be attributed to irregular segregation of trivalents in meiotic anaphase I. In male meiosis, more than 50% of aneuploid secondary spermatocytes are produced. The cytophotometric measurements of the relative FeulgenDNA content of cytologically mature, morphologically normal spermatozoa revealed a significantly greater variation in F₁ males as compared to M. poschiavinus and the laboratory mouse. This difference is regarded as being due to the presence of a considerable fraction of aneuploid spermatozoa. Obviously, they are derived from the aneuploid precursor cells and have developed normally in spite of their abnormal number of chromosomes. However, the frequency of malformed spermatozoa was also higher in F₁ males than in the parental strains. The additional analysis of the number of spermatozoa, their motility and the respective proportions of living or dead spermatozoa and of spermatozoa with normal or abnormal acrosomal caps did not show differences between F₁ males and the parental strains. The head area of F₁ spermatozoa was markedly reduced.