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EFFECT OF 5-METHOXYTRYPTOPHOL ON THE REPRODUCTIVE SYSTEM OF MALE RATS

It is a well-known fact that the pineal gland contains a large amount of indole substances chemically related to serotonin (Axelrod, 1970). Among these compounds, melatonin has been the most extensively studied (Reiter & Sorrentino, 1970). Many reports have described that melatonin displays an evident inhibitory influence on the sexual functions when administered parenterally or by implant into the hypothalamus (Chu, Wurtman & Axelrod, 1964; Fraschini, Mess & Martini, 1968; Debeljuk, 1969; Debeljuk, Feder & Paulucci, 1970a). Another indole, 5-methyoxytryptophol, isolated from the pineal gland by McIsaacs, Taborsky & Farrell (1964), was also shown to have inhibitory effects on the sexual system, although some of its properties seem to be somewhat different from those of melatonin (Fraschini, 1969). Since the effect of the treatment with 5-methoxytryptophol