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EFFECT OF ANTISERUM TO OVINE LUTEINIZING HORMONE ON CORPUS LUTEUM FUNCTION IN MICE

Summary.: The effect of an antiserum to ovine LH was studied on implantation and deciduoma formation in mice. Administration of the LH antiserum on Day 4 of pregnancy and pseudopregnancy inhibited, respectively, the implantation and decidual cell reaction. The administration of progesterone at the same time as the antiserum overcame the inhibitory effects of the antibodies to LH. The results of these studies indicate that the anti-implantation activity of the LH antiserum is manifest by its inhibition of progesterone synthesis by the CL.