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DISTRIBUTION OF [¹⁴C]-CHLOROHYDRIN IN MICE AND RATS

Alpha-chlorohydrin (3-chlor-1,2 propanediol) possesses antifertility properties when administered to male rats, hamsters, guinea-pigs, rams and monkeys (Ericsson, 1968; Ericsson & Norland, 1970). The compound is thought to exert its action on the epididymis, since high doses of -chlorohydrin cause vascular disturbances in the proximal part of the epididymis (Gunn, Gould & Anderson, 1969; Samojlik & Chang, 1970; Kreider & Dutt, 1971). There is also a time delay between administration of the drug and the onset of inhibition of fertility (Ericsson, 1968; Turner, 1971). Impaired sperm motility which has been observed (Coppola, 1969; Samojlik & Chang, 1970), has been thought to be due to oxygen deficiency in the epididymis following vascular trauma. Coppola (1969) and Gunn et al. (1969) suggested that -chlorohydrin might act as a metabolic antagonist to

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				K. B. Jelks and M. G. Miller {{alpha}}-Chlorohydrin Inhibits Glyceraldehyde-3-Phosphate Dehydrogenase in Multiple Organs as Well as in Sperm Toxicol. Sci., July 1, 2001; 62(1): 115 - 123. [Abstract] [Full Text] [PDF]