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INHIBITION OF PROGESTERONE SYNTHESIS IN VITRO BY PROSTAGLANDIN F₂

Prostaglandins have been shown to be potent stimulants of CL steroid production in vitro (Pharriss & Wyngarden, 1969; Marsh, 1971; Speroff & Ramwell, 1970), yet prostaglandin F₂ (PGF₂) given in vivo effectively inhibits progesterone secretion in rats, rabbits, guinea-pigs, sheep and the rhesus monkey (see Pharriss, Tillson & Erickson, 1972, for review). A better understanding of the possible rôle of prostaglandins has been confused by these paradoxical findings. In such studies, it would be of value to have as an experimental model, an in-vitro system in which it is possible to duplicate the inhibitory effects on luteal steroidogenesis seen with the use of PGF₂ administered in vivo. This communication describes an in-vitro method in which sections of rabbit CL are maintained

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